Living Cell Transplants Without Immunosuppression

A Proven Premise that Requires a Practical Solution for Immune-System Rejection

Proven Approach

The premise for Encapsulife's functional cure approach has been proven in parts by other research trials of other organizations — where there were partial successes. In particular, reports of the 1999 - 2000 Edmonton Studies, demonstrated that diabetes reversal could be achieved by implanting islet cells — with use of immunosuppression drugs. Regrettably, the cocktail of immunosuppression used in the Edmonton studies, while enabling islet cell functionality, inflicted highly negative side-effects on the diabetic patients.

Encapsulife's immunoisolation process has proven entirely benign to host patients and is a significant improvement over the Edmonton research experience because Encapsulife's approach does not involve any immunosuppression therapies.

Progress Toward Protecting Islet Cells In the Diabetic Host

ANY foreign tissue inserted or transplanted into the human body triggers the body's immune system to attack and defeat the foreign tissue. "Rejection" occurs when the tissue (a donated organ, for example) is defeated by the new host's immune system. Historically, there have been two means of protecting the new donated tissue in the new host: immunosuppression and immunoisolation.

Encapsulife's Solution: Immunoisolation of Transplanted Islet Cells

Immunoisolation is achieved by encapsulating pancreatic Beta cells within a multi-layered microscopic polymer capsule, and then transplanting these encapsulated cells into the new host with a simple 15-minute laproscoptic procedure. The encapsulated Beta cells are anchored but not attached in the peritoneal cavity of the new host where there is sufficient fluid exchange to provide nutrients to the encapsulated islets, as well as triggers to the encapsulated islets to produce insulin. The insulin, which by itself in the body does not trigger an autoimmune reaction, is absorbed into the blood stream to bond with glucose — and provide energy and growth to each and every cell of the human host. Through repeated trials, the polymer components of immuno-isolation capsules — 97% water and 3% cellulose — are completely benign to the host.