Notable Publications by Encapsulife's Founder, Dr. Taylor G. Wang

February 15, 2008:
Successful Allotransplantation of Encapsulated Islets in Pancreatectomized Canines for Diabetic Management Without the Use of Immunosuppression

Results of Encapsulife's successful large animal trials on its novel immunoisolation encapsulation system were published on in peer-reviewed research. In this landmark research, encapsulated canine pancreatic islets were transplanted into dogs rendered diabetic by total pancreatectomy. No immunosuppression or anti-inflammatory therapy was used.

— by Taylor G. Wang, Jamie Adcock, Willem Kuhtreiber, Deng Qiang, Kenneth J. Salleng, Irina Trenary and Phil Williams, published in Transplantation, the Official Journal of the Transplantation Society, Volume 85, Issue 3, Page 331, February 15, 2008 (abstract and link to full article)

April 27, 2006:
A Novel Method of Monitoring Response to Islet Transplantation: Bioluminescent Imaging of an NF-kB Transgenic Mouse Model

— by David J. Roth, E Duco Jansen, Alvin C. Powers and Taylor G. Wang, published in Transplantation, the Official Journal of the Transplantation Society, Volume 81, Issue 8, Page 1185, April 27, 2006 (abstract and link to full article)

October, 2001:
Microencapsulation Methods: PMCG capsules

— by Taylor G. Wang, chapter in Methods of Tissue Engineering, October, 2001 (preview of book online)

2001:
A two-step process for controlling the surface smoothness of polyelectrolyte-based microcapsules

— by I. Lacik, A.V. Anilkumar and Taylor G. Wang, published in Journal of Microencapsulation, Volume 18, Issue 4, Page 479, 2001 (abstract and link to full article)

2001:
A novel Reactor for Making Uniform Capsules

— by A. V. Anilkuma, I. Lacik and Taylor G. Wang, published in Biotechnology and Bioengineering, Volume 75, Issue 5, Page 581, 2001 (abstract and link to full article)

August 7, 2000:
Progress in Bioartificial Pancreas

— by Taylor G. Wang, published in e-biomed: The Journal of Regenerative Medicine, Volume 1, Issue 6, Page 93, 2000 (abstract and link to full article)

June 6, 2000:
Core Centering of Immiscible Compound Drops In Capillary Oscillations: Experimental Observations

— by A. V. Anilkumar1, A. B. Hmelo and Taylor G. Wang, published in Journal of Colloid and Interface Science, Volume 242, Issue 2, Page 465, 2000 (abstract and link to full article)

May, 2000:
Bioartificial Pancreas

— by Taylor G. Wang and Robert P. Lanza, chapter in Principles of Tissue Engineering, Second Edition, May, 2000 (preview of book online)

1999:
Polymer Membranes for Cell Encapsulation

— by Taylor G. Wang, chapter in Cell Encapsulation Technology and Therapeutics, 1999 (preview of chapter online)

January, 1998:
New Technologies for Bioartificial Organs

Results of efforts to incorporate pore size distribution into a new design of capsules for immunoisolation of living cells, using larger pores to allow the immune system to enter the membrane, and smaller pores inside the membrane to act as traps to prevent or delay most of the immune system from reaching the encapsulated living cells were published. Limited animal studies supported the advantages of this new entrapment model over the current model, and paved the way for systematic studies to determine optimal capsule design for human transplantation.

— by Taylor G. Wang, published in Artificial Organs, Volume 22, Issue 1, Pages 68-74, January 1998 (abstract and link to full article)

1997:
A screening of Polymers as Biomaterials for Cell Encapsulation

— by D. Hunkeler, A. Prokop, A. Powers, M. Haralson, S. Dimari and T. Wang, published in Polymer News, Volume 22, Issue 7, Pages 232-240, 1997 (not available online)

April, 1997:
An Encapsulation System for the Immunoisolation of Pancreatic Islets

Results of testing new polymer candidates suitable for encapsulation of living cells were published. Promising combinations and a novel multiloop chamber reactor were developed. Encapsulated rat islets demonstrated glucose-stimulated insulin secretion in vitro, and reversed diabetes in mice. The new capsule formulation and encapsulation system enabled independent adjustments of capsule size, wall thickness, mechanical strength, and permeability.

— by Taylor Wang, Igor Lacik, Marcela Brissova, Amrutur V. Anilkumar, Ales Prokop, David Hunkeler, Ray Green, Keivan Shahrokhi and Alvin C. Powers, published in Nature Biotechnology, Volume 15, Pages 358-362, April 1997 (abstract and link to full article)